Effects of mevalonate on the statin-induced suppression of RANKL. FLSs from RA patients (patients number 1 through 3) were cultured in the presence of TNF-α (20 ng/ml), and then atorvastatin (50 to 100 μM) and mevalonate (100 μM) were added for 24 hours. RANKL expressions were analyzed with RT-PCR (A) and Western blotting (B). A representative experiment from three independent experiments is shown.
Kim et al. Arthritis Research & Therapy 2012 14:R187 doi:10.1186/ar4018