Table 1

Demographic, clinical and laboratory data of systemic lupus erythematosus (SLE) patients at the time of the study

Active LN

No active LN

History of LN

No history of LN


Total number

21

15

33

Male/female, number

4/17

3/12

2/31

Age, years, median (range)

38 (16 to 53)

46 (18 to 61)

48 (20 to 81)

SLEDAI, mean ± SD

13.7 ± 3.7 ***,+++

2.7 ± 1.7

2.8 ± 2.7

Anti-dsDNA antibody, IU/ml, median (range)

140 (3 to 1,000) **, +

19 (3 to 432)

20.5 (3 to 1000)

C3, g/l, median (range)

0.55 (0.27 to 1.13)***,++

0.93 (0.43 to 1.48)

0.97 (0.31 to 11.4)

C4 (g/l), median (range)

0.08 (0.03- 0.3)*,+

0.16 (0.06 to 0.3)

0.12 (0.02 to 1.04)

CRP, mg/I, median (range)

5 (5 to 121)

5 ( 5 to 21)

5 (5 to 33)

eGFR, ml/min

72 (24 to 142)

81 (45 to 145)

89 (31 to 140)

Serum creatinine, µmol/l, median (range)

75 (46 to 406)

71 (51 to 126)

62 (47 to 141)

24-hr proteinuria, g/24hr

1.5 (0.3 to 8.4)***,+++

0.3 (0.2 to 2.5) # # #

0.0 (0.0 to 0.1)

Urine creatinine, mmol/l, median (range)

7.6 (0.6 to 21.3)

4.3 (1.6 to 15.7)

6.2 (0.7 to 14.9)

With/without treatment, number

12/9

13/2

21/12

Patients using prednisone, number (%), dose, mg/day, median (range)

10 (47.6%)

7.5 (2.5 to 60)

10 (66.6%)

10 (5 to 60)

8 (24.2%)

5 (1.25 to 10)

Patients taking hydroxychloroquine, number (%), dose, mg/day, median (range)

8 (38%)

350 ( 200 to 600)

2 (13.3%)

400 (400)

14 (42.2%)

400 (200 to 600)

Patients using azathioprine, number (%), dose, mg/day, median (range)

3 (14.3%)

100 (75 to 150)

7 (46.6%)

75 (50 to150)

6 (18.2%)

125 (75 to 150)


+Indicates difference between active lupus nephritis (LN) patients and patients with no active LN but with history of LN (+P ≤ 0.05, ++P ≤ 0.005, +++P ≤ 0.0005). *Indicates difference between active and inactive SLE patients (*P = 0.05,**P ≤ 0.005, ***P ≤ 0.0005). #Indicates difference between patients without active LN but with history of LN and inactive SLE patients with no history of LN (#P = 0.05, ##P ≤ 0.005, ###P ≤ 0.0005). Anti-dsDNA: anti-double stranded DNA; C3: Complement 3; C4 Complement 4; CRP: C-reactive protein; eGFR: estimated glomerular filtration rate; SLEDAI: systemic lupus erythematosus disease activity index.

Abdulahad et al. Arthritis Research & Therapy 2012 14:R184   doi:10.1186/ar4015

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