Expression of high mobility group box 1 (HMGB1) receptors in a renal biopsy from a patient with active lupus nephritis (LN) and in control renal tissue. Representative staining for RAGE, TLR2 and TLR4 in active LN (D,E,F) and control renal tissue (A,B,C), respectively. Renal tissue of an active LN patient shows strong cytoplasmic/extracellular expression for HMGB1 receptors in tubular cells, interstitial infiltrates, and glomeruli in comparison to control tissue.
Abdulahad et al. Arthritis Research & Therapy 2012 14:R184 doi:10.1186/ar4015