Table 2

Genes significantly upregulated or downregulated by hypoxia and/or dimethyloxalylglycine in human rheumatoid arthritis fibroblast-like synoviocytes

Genes that change only in response to hypoxia

Genes that change only in response to DMOG

Genes that change in response to hypoxia and DMOG


TGF-β1 (2*)

NRP2 (-2*)

VEGF (8*/31*)

HPSE (-2*)

ID3 (-3*)

PLAU (-2*/-2*)

FIGF (-2*)

EFNB2 (5*)

LEP (108***/85***)

CXCL-5 (-2*)

CCL2 (-4*)

HIF1A (-2*/-2*)

CCL-11 (-9*)

HAND2 (-2*/-6*)

EFNA3 (2*/9*)

ANGPTL4 (12**/48**)


Genes significantly upregulated or downregulated by a factor ≥2. Genes from Figure 1b,c that change following 24 hours of hypoxia and in response to stimulation with the hypoxia-inducible factor activator dimethyloxalylglycine (DMOG) in rheumatoid arthritis fibroblast-like synoviocytes from five and three patients, respectively. Data presented as mean fold-change. Genes that changed significantly (P < 0.05) by a factor ≥2-fold were analysed by paired Student's t test comparing ΔCt values: *P < 0.05, **P < 0.001, ***P < 0.001. ANGPTL, angiopoietin-like; EFNA3, ephrin A3;EFNB2, ephrin B2; FIGF, C-fos-induced growth factor (VEGF D); HAND2, Heart and neural crest derivatives expressed 2; HPSE, heparanase; ID3, inhibitor of DNA-binding 3, dominant negative helix-loop-helix protein; LEP, leptin; NRP2, neuropillin 2; PLAU, plasminogen activator urokinase; TGF, transforming growth factor; VEGF, vascular endothelial growth factor.

Larsen et al. Arthritis Research & Therapy 2012 14:R180   doi:10.1186/ar3934

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