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Open Access Highly Accessed Research article

Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA

Helene Larsen1*, Barbara Muz2, Tak L Khong3, Marc Feldmann1 and Ewa M Paleolog1

Author Affiliations

1 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, Arthritis Research Campaign Building, 65 Aspenlea Road, London W6 8LH, UK

2 Department of Radiation Oncology, Cancer Biology Division, St. Louis School of Medicine, Washington University, 4511 Forest Park Avenue, St. Louis, MO 63108, USA

3 Department of Surgery, Pinderfields Hospital Aberford Road, Wakefield WF1 4DG, UK

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Arthritis Research & Therapy 2012, 14:R180  doi:10.1186/ar3934

Published: 6 August 2012

Additional files

Additional file 1:

Table presenting the genes on Human Angiogenesis RT² Profiler™ PCR Arrays upregulated or downregulated by hypoxia in RA FLS from a single patient. PCR array results presented as the fold-change in gene expression versus normoxia.

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Open Data

Additional file 2:

Figures presenting supplementary data.

Format: PDF Size: 345KB Download file

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Open Data