Table 4

Allele and genotype frequencies in a case control cohort of patients with RA.

dbSNP identity

Allele/

Geno

type

Number of patients with RA (%)

Number of controls (%)

P value

P value after multivariate logistic regression

P value after multiple testing correction (Bonferroni method)

Odds Ratio (%95 CI)

HWE test for case (df = 1)

HWE test for control (df = 1)


rs7827474

C

31(0.059)

1(0.003)

3.68E-05

3.31E-03

5.83E-04

20.014257 (2.718505~147.349579)

G

491(0.941)

317(0.997)

CC

1(0.004)

0(0.000

0.0002

0.000186

0.929804

0.968272

CG

29(0.111)

1(0.006)

GG

231(0.885)

158(0.994)

rs3808540*

A

307(0.590)

196(0.613)

0.525421

0.911852 (0.685840~1.212343)

G

213(0.410)

124(0.388)

AA

91(0.350)

64(0.400)

0.506516

0.923195

0.185552

AG

125(0.481)

68(0.425)

GG

44(0.169)

28(0.175)

rs11774422

A

4(0.008)

1(0.003)

0.414051

2.425855 (0.269936~21.800669)

G

526(0.992)

319(0.997)

AG

4(0.015)

1(0.006)

0.412665

0.901484

0.968372

GG

261(0.985)

159(0.994)

rs7011926

A

287(0.542)

172(0.541)

0.985804

1.002536 (0.758458~1.325161)

G

243(0.458)

146(0.459)

AA

77(0.291)

55(0.346)

0.079064

0.86122

0.006761

AG

133(0.502)

62(0.390)

GG

55(0.208)

42(0.264)

rs34456327

A

7(0.013)

312(1.000)

0.040401

G

7(0.013)

0(0.000)

AA

257(0.981)

156(1.000)

0.221769

3.33E-15

1

AG

3(0.011)

0(0.000)

GG

2(0.008)

0(0.000)

rs7821248

A

2(0.004)

1(0.003)

0.874655

1.213178 (0.109552~13.434785)

G

516(0.996)

313(0.997)

AA

1(0.004)

0(0.000)

0.323685

5.55E-16

0.968069

AG

0(0.000)

1(0.006)

GG

258(0.996)

156(0.994)

rs13276893

A

359(0.730)

218(0.717)

0.699646

1.064841 (0.773866~1.465222)

G

133(0.270)

86(0.283)

AA

122(0.496)

77(0.507)

0.238757

0.003729

0.641532

AG

115(0.467)

64(0.421)

GG

9(0.037)

11(0.072)

rs2220972

A

1(0.002)

0(0.000)

0.438632

G

533(0.998)

320(1.000)

AG

1(0.004)

0(0.000)

0.438364

0.975544

1

GG

266(0.996)

160(1.000)

rs34282382

A

502(0.954)

298(0.949)

0.725735

1.123042 (0.587088~2.148271)

C

24(0.046)

16(0.051)

AA

240(0.913)

141(0.898)

0.612061

0.521732

0.501138

AC

22(0.084)

16(0.102)

CC

1(0.004)

0(0.000)

rs7840971

A

5(0.009)

1(0.003)

0.285353

3.049713 (0.354681~26.222826)

G

523(0.991)

319(0.997)

AA

2(0.008)

0(0.000)

0.511044

3.00E-15

0.968372

AG

1(0.004)

1(0.006)

GG

261(0.989)

159(0.994)

rs7841304

A

2(0.004)

1(0.003)

0.887385

1.189516 (0.107391~13.175623)

G

496(0.996)

295(0.997)

AG

2(0.008)

1(0.007)

0.887172

0.949269

0.967107

GG

247(0.992)

147(0.993)

rs7818073

A

4(0.008)

0(0.000)

0.12006

T

528(0.992)

320(1.000)

AA

1(0.004)

0(0.000)

0.403133

4.44E-16

1

AT

2(0.008)

0(0.000)

TT

263(0.989)

160(1.000)

rs7841425

A

184(0.365)

91(0.318)

0.183639

1.232143 (0.905616~1.676401)

C

320(0.635)

195(0.682)

AA

46(0.183))

17(0.119)

0.250595

0.000748

0.330884

AC

92(0.365)

57(0.399)

CC

114(0.452)

69(0.483)


CI, confidence interval; HWE, Hardy-Weinberg equilibrium.

Chang et al. Arthritis Research & Therapy 2012 14:R176   doi:10.1186/ar3929

Open Data