Table 4 |
|||||||||
|
Allele and genotype frequencies in a case control cohort of patients with RA. |
|||||||||
|
dbSNP identity |
Allele/ Geno type |
Number of patients with RA (%) |
Number of controls (%) |
P value |
P value after multivariate logistic regression |
P value after multiple testing correction (Bonferroni method) |
Odds Ratio (%95 CI) |
HWE test for case (df = 1) |
HWE test for control (df = 1) |
|
|
|||||||||
|
rs7827474 |
C |
31(0.059) |
1(0.003) |
3.68E-05 |
3.31E-03 |
5.83E-04 |
20.014257 (2.718505~147.349579) |
||
|
G |
491(0.941) |
317(0.997) |
|||||||
|
CC |
1(0.004) |
0(0.000 |
0.0002 |
0.000186 |
0.929804 |
0.968272 |
|||
|
CG |
29(0.111) |
1(0.006) |
|||||||
|
GG |
231(0.885) |
158(0.994) |
|||||||
|
rs3808540* |
A |
307(0.590) |
196(0.613) |
0.525421 |
0.911852 (0.685840~1.212343) |
||||
|
G |
213(0.410) |
124(0.388) |
|||||||
|
AA |
91(0.350) |
64(0.400) |
0.506516 |
0.923195 |
0.185552 |
||||
|
AG |
125(0.481) |
68(0.425) |
|||||||
|
GG |
44(0.169) |
28(0.175) |
|||||||
|
rs11774422 |
A |
4(0.008) |
1(0.003) |
0.414051 |
2.425855 (0.269936~21.800669) |
||||
|
G |
526(0.992) |
319(0.997) |
|||||||
|
AG |
4(0.015) |
1(0.006) |
0.412665 |
0.901484 |
0.968372 |
||||
|
GG |
261(0.985) |
159(0.994) |
|||||||
|
rs7011926 |
A |
287(0.542) |
172(0.541) |
0.985804 |
1.002536 (0.758458~1.325161) |
||||
|
G |
243(0.458) |
146(0.459) |
|||||||
|
AA |
77(0.291) |
55(0.346) |
0.079064 |
0.86122 |
0.006761 |
||||
|
AG |
133(0.502) |
62(0.390) |
|||||||
|
GG |
55(0.208) |
42(0.264) |
|||||||
|
rs34456327 |
A |
7(0.013) |
312(1.000) |
0.040401 |
|||||
|
G |
7(0.013) |
0(0.000) |
|||||||
|
AA |
257(0.981) |
156(1.000) |
0.221769 |
3.33E-15 |
1 |
||||
|
AG |
3(0.011) |
0(0.000) |
|||||||
|
GG |
2(0.008) |
0(0.000) |
|||||||
|
rs7821248 |
A |
2(0.004) |
1(0.003) |
0.874655 |
1.213178 (0.109552~13.434785) |
||||
|
G |
516(0.996) |
313(0.997) |
|||||||
|
AA |
1(0.004) |
0(0.000) |
0.323685 |
5.55E-16 |
0.968069 |
||||
|
AG |
0(0.000) |
1(0.006) |
|||||||
|
GG |
258(0.996) |
156(0.994) |
|||||||
|
rs13276893 |
A |
359(0.730) |
218(0.717) |
0.699646 |
1.064841 (0.773866~1.465222) |
||||
|
G |
133(0.270) |
86(0.283) |
|||||||
|
AA |
122(0.496) |
77(0.507) |
0.238757 |
0.003729 |
0.641532 |
||||
|
AG |
115(0.467) |
64(0.421) |
|||||||
|
GG |
9(0.037) |
11(0.072) |
|||||||
|
rs2220972 |
A |
1(0.002) |
0(0.000) |
0.438632 |
|||||
|
G |
533(0.998) |
320(1.000) |
|||||||
|
AG |
1(0.004) |
0(0.000) |
0.438364 |
0.975544 |
1 |
||||
|
GG |
266(0.996) |
160(1.000) |
|||||||
|
rs34282382 |
A |
502(0.954) |
298(0.949) |
0.725735 |
1.123042 (0.587088~2.148271) |
||||
|
C |
24(0.046) |
16(0.051) |
|||||||
|
AA |
240(0.913) |
141(0.898) |
0.612061 |
0.521732 |
0.501138 |
||||
|
AC |
22(0.084) |
16(0.102) |
|||||||
|
CC |
1(0.004) |
0(0.000) |
|||||||
|
rs7840971 |
A |
5(0.009) |
1(0.003) |
0.285353 |
3.049713 (0.354681~26.222826) |
||||
|
G |
523(0.991) |
319(0.997) |
|||||||
|
AA |
2(0.008) |
0(0.000) |
0.511044 |
3.00E-15 |
0.968372 |
||||
|
AG |
1(0.004) |
1(0.006) |
|||||||
|
GG |
261(0.989) |
159(0.994) |
|||||||
|
rs7841304 |
A |
2(0.004) |
1(0.003) |
0.887385 |
1.189516 (0.107391~13.175623) |
||||
|
G |
496(0.996) |
295(0.997) |
|||||||
|
AG |
2(0.008) |
1(0.007) |
0.887172 |
0.949269 |
0.967107 |
||||
|
GG |
247(0.992) |
147(0.993) |
|||||||
|
rs7818073 |
A |
4(0.008) |
0(0.000) |
0.12006 |
|||||
|
T |
528(0.992) |
320(1.000) |
|||||||
|
AA |
1(0.004) |
0(0.000) |
0.403133 |
4.44E-16 |
1 |
||||
|
AT |
2(0.008) |
0(0.000) |
|||||||
|
TT |
263(0.989) |
160(1.000) |
|||||||
|
rs7841425 |
A |
184(0.365) |
91(0.318) |
0.183639 |
1.232143 (0.905616~1.676401) |
||||
|
C |
320(0.635) |
195(0.682) |
|||||||
|
AA |
46(0.183)) |
17(0.119) |
0.250595 |
0.000748 |
0.330884 |
||||
|
AC |
92(0.365) |
57(0.399) |
|||||||
|
CC |
114(0.452) |
69(0.483) |
|||||||
|
|
|||||||||
|
CI, confidence interval; HWE, Hardy-Weinberg equilibrium. |
|||||||||
|
Chang et al. Arthritis Research & Therapy 2012 14:R176 doi:10.1186/ar3929 |
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