Table 3

Allele and genotype frequencies in a case control cohort of patients with AS.

dbSNP identity

Allele/

Geno

type

Number of patients with RA (%)

Number of controls (%)

P value

P value after multivariate logistic regression

P value after multiple testing correction (Bonferroni method)

Odds Ratio (%95 CI)

HWE test for case (df = 1)

HWE test for control (df = 1)


rs7827474

C

1(0.010)

1(0.003)

0.395319

3.138614 (0.194542~50.636475)

G

101(0.990)

317(0.997)

CG

1(0.020)

1(0.006)

0.394186

0.943634

0.968272

GG

50(0.980)

158(0.994)

rs3808540*

A

64(0.627)

196(0.613)

0.786888

1.065521 (0.672573~1.688048}

G

38(0.373)

124(0.388)

AA

19(0.373)

64(0.400)

0.475302

0.518298

0.185552

AG

26(0.510)

68(0.425)

GG

6(0.118)

28(0.175)

rs11774422

A

0(0.000)

1(0.003)

0.571929

G

102(1.000)

319(0.997)

AG

0(0.000)

1(0.006)

0.571472

1

0.968372

GG

51(1.000)

159(0.994)

rs34456327

A

98(1.000)

312(1.000)

AA

49(1.000)

156(1.000)

rs7821248

A

0(0.000)

1(0.003)

0.575955

G

98(1.000)

313(0.997)

AG

0(0.000)

1(0.006)

0.57549

1

0.968069

GG

49(1.000)

156(0.994)

rs13276893

A

69(0.704)

218(0.717)

0.804077

0.938627 (0.569058~1.548209)

G

29(0.296)

86(0.283)

AA

22(0.449)

77(0.507)

0.475953

0.116312

0.641532

AG

25(0.510)

64(0.421)

GG

2(0.041)

11(0.072)

rs2220972

G

102(1.000)

320(1.000)

GG

51(1.000)

160(1.000)

rs1032551

C

30(0.306)

110(0.374)

0.2236

0.737968 (0.451984~1.204903)

G

68(0.694)

184(0.626)

CC

0(0.000)

13(0.088)

0.096659

CG

30(0.612)

84(0.571)

GG

19(0.388)

50(0.340)

rs34282382

A

102(1.000)

298(0.949)

0.020115

C

0(0.000)

6(0.051)

AA

51(1.000)

141(0.898)

0.017687

1

0.501138

AC

0(0.000)

16(0.102)

rs7840971

A

0(0.000)

1(0.003)

0.571929

G

102(1.000)

319(0.997)

AG

0(0.000)

1(0.006)

0.571472

1

0.968372

GG

51(1.000)

159(0.994)

rs7841304

A

0(0.000)

1(0.003)

0.576716

G

92(1.000)

295(0.997)

AG

0(0.000)

1(0.007)

0.576223

1

0.967107

GG

46(1.000)

147(0.993)

rs7818073

T

102(1.000)

320(1.000)

TT

51(1.000)

160(1.000)

rs7841425

A

15(0.153)

91(0.318)

0.001611

0.002234

0.01396

0.387263 (0.211775~0.708169}

C

83(0.847)

195(0.682)

AA

0(0.000)

17(0.119)

0.007879

0.005902

0.205909

0.330884

AC

15(0.306)

57(0.399)

CC

34(0.694)

69(0.483)


CI, confidence interval; HWE, Hardy-Weinberg equilibrium.

Chang et al. Arthritis Research & Therapy 2012 14:R176   doi:10.1186/ar3929

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