Table 3 |
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|
Allele and genotype frequencies in a case control cohort of patients with AS. |
|||||||||
|
dbSNP identity |
Allele/ Geno type |
Number of patients with RA (%) |
Number of controls (%) |
P value |
P value after multivariate logistic regression |
P value after multiple testing correction (Bonferroni method) |
Odds Ratio (%95 CI) |
HWE test for case (df = 1) |
HWE test for control (df = 1) |
|
|
|||||||||
|
rs7827474 |
C |
1(0.010) |
1(0.003) |
0.395319 |
3.138614 (0.194542~50.636475) |
||||
|
G |
101(0.990) |
317(0.997) |
|||||||
|
CG |
1(0.020) |
1(0.006) |
0.394186 |
0.943634 |
0.968272 |
||||
|
GG |
50(0.980) |
158(0.994) |
|||||||
|
rs3808540* |
A |
64(0.627) |
196(0.613) |
0.786888 |
1.065521 (0.672573~1.688048} |
||||
|
G |
38(0.373) |
124(0.388) |
|||||||
|
AA |
19(0.373) |
64(0.400) |
0.475302 |
0.518298 |
0.185552 |
||||
|
AG |
26(0.510) |
68(0.425) |
|||||||
|
GG |
6(0.118) |
28(0.175) |
|||||||
|
rs11774422 |
A |
0(0.000) |
1(0.003) |
0.571929 |
|||||
|
G |
102(1.000) |
319(0.997) |
|||||||
|
AG |
0(0.000) |
1(0.006) |
0.571472 |
1 |
0.968372 |
||||
|
GG |
51(1.000) |
159(0.994) |
|||||||
|
rs34456327 |
A |
98(1.000) |
312(1.000) |
||||||
|
AA |
49(1.000) |
156(1.000) |
|||||||
|
rs7821248 |
A |
0(0.000) |
1(0.003) |
0.575955 |
|||||
|
G |
98(1.000) |
313(0.997) |
|||||||
|
AG |
0(0.000) |
1(0.006) |
0.57549 |
1 |
0.968069 |
||||
|
GG |
49(1.000) |
156(0.994) |
|||||||
|
rs13276893 |
A |
69(0.704) |
218(0.717) |
0.804077 |
0.938627 (0.569058~1.548209) |
||||
|
G |
29(0.296) |
86(0.283) |
|||||||
|
AA |
22(0.449) |
77(0.507) |
0.475953 |
0.116312 |
0.641532 |
||||
|
AG |
25(0.510) |
64(0.421) |
|||||||
|
GG |
2(0.041) |
11(0.072) |
|||||||
|
rs2220972 |
G |
102(1.000) |
320(1.000) |
||||||
|
GG |
51(1.000) |
160(1.000) |
|||||||
|
rs1032551 |
C |
30(0.306) |
110(0.374) |
0.2236 |
0.737968 (0.451984~1.204903) |
||||
|
G |
68(0.694) |
184(0.626) |
|||||||
|
CC |
0(0.000) |
13(0.088) |
0.096659 |
||||||
|
CG |
30(0.612) |
84(0.571) |
|||||||
|
GG |
19(0.388) |
50(0.340) |
|||||||
|
rs34282382 |
A |
102(1.000) |
298(0.949) |
0.020115 |
|||||
|
C |
0(0.000) |
6(0.051) |
|||||||
|
AA |
51(1.000) |
141(0.898) |
0.017687 |
1 |
0.501138 |
||||
|
AC |
0(0.000) |
16(0.102) |
|||||||
|
rs7840971 |
A |
0(0.000) |
1(0.003) |
0.571929 |
|||||
|
G |
102(1.000) |
319(0.997) |
|||||||
|
AG |
0(0.000) |
1(0.006) |
0.571472 |
1 |
0.968372 |
||||
|
GG |
51(1.000) |
159(0.994) |
|||||||
|
rs7841304 |
A |
0(0.000) |
1(0.003) |
0.576716 |
|||||
|
G |
92(1.000) |
295(0.997) |
|||||||
|
AG |
0(0.000) |
1(0.007) |
0.576223 |
1 |
0.967107 |
||||
|
GG |
46(1.000) |
147(0.993) |
|||||||
|
rs7818073 |
T |
102(1.000) |
320(1.000) |
||||||
|
TT |
51(1.000) |
160(1.000) |
|||||||
|
rs7841425 |
A |
15(0.153) |
91(0.318) |
0.001611 |
0.002234 |
0.01396 |
0.387263 (0.211775~0.708169} |
||
|
C |
83(0.847) |
195(0.682) |
|||||||
|
AA |
0(0.000) |
17(0.119) |
0.007879 |
0.005902 |
0.205909 |
0.330884 |
|||
|
AC |
15(0.306) |
57(0.399) |
|||||||
|
CC |
34(0.694) |
69(0.483) |
|||||||
|
|
|||||||||
|
CI, confidence interval; HWE, Hardy-Weinberg equilibrium. |
|||||||||
|
Chang et al. Arthritis Research & Therapy 2012 14:R176 doi:10.1186/ar3929 |
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