Open Access Research article

Monocyte populations as markers of response to adalimumab plus MTX in rheumatoid arthritis

Luis Chara1, Ana Sánchez-Atrio2, Ana Pérez2, Eduardo Cuende2, Fernando Albarrán2, Ana Turrión2, Julio Chevarria1, Miguel A Sánchez1, Jorge Monserrat1, Antonio de la Hera1, Alfredo Prieto1, Ignacio Sanz3, David Diaz1 and Melchor Alvarez-Mon12*

Author Affiliations

1 Department of Medicine, University of Alcalá, N-II km 33, Alcala de Henares 28871, Spain

2 Immune System Diseases and Oncology Service, University Hospital "Príncipe de Asturias", N-II km 33, Alcala de Henares 28871, Spain

3 Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA

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Arthritis Research & Therapy 2012, 14:R175  doi:10.1186/ar3928

Published: 27 July 2012

Additional files

Additional file 1:

Absolute number of circulating monocytes and of their subsets in untreated naive and MTX-treated active patients with RA and healthy controls. The absolute number (cells/μl) of circulating monocytes (panel A), CD14+highCD16- (panel B), CD14+highCD16+ (panel C) and CD14+lowCD16+ monocytes (panel D) of untreated naive and MTX-treated active patients with RA and of healthy controls, are shown as the mean ± SEM. * Significant difference between patients with RA and healthy controls.

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Open Data

Additional file 2:

Absolute number of circulating monocytes and of their subsets in untreated naive and MTX-treated active patients with RA and healthy controls. Panel A represents flow cytometry analysis of circulating monocytes from a representative patient. The percentage of circulating monocytes, CD14+highCD16- (panel B), CD14+highCD16+ (panel C) and CD14+lowCD16+ monocytes (panel D) of untreated naive and MTX-treated active patients with RA and of healthy controls, are shown as the mean ± SEM. * Significant difference between patients with RA and healthy controls.

Format: EPS Size: 2.1MB Download file

Open Data