Table 1

Quantification of lymphocytic infiltrates in the salivary glands of gene-delivered mouse groups

Disease stage

Salivary glands

Lacrimal glands

Treatment

LF

Meana

LF

Mean


Saline

5/6b (83%)c

2.3 ± 1.5

4/6 (67%)

2.8 ± 1.3


Pre-disease

Lac-Z

7/7 (100%)

3.0 ± 2.4

6/7 (86%)

1.5 ± 0.7

IL-27

6/7 (86%)

4.3 ± 2.2

2/7d (29%)

2.0 ± 1.4


Clinical disease

Lac-Z

7/7 (100%)

3.4 ± 2.4

4/7 (57%)

2.5 ± 1.0

IL-27

7/7 (100%)

3.4 ± 1.3

2/7 (29%)

4.5 ± 5.0


aMean lymphocytic foci (LF) score of each gland in mouse ± standard error of the mean per histological salivary gland section; bnumber of mice; cpercentage of mice; dP < 0.05 by chi-squared test. IL-27, rAAV2-IL27-treated groups; LacZ, rAAV2-LacZ-treated groups; saline, saline-treated groups.

Lee et al. Arthritis Research & Therapy 2012 14:R172   doi:10.1186/ar3925

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