Measurement of stimulated saliva flow rates (SFRs). One week prior to treatment, saliva was collected and measured to determine the baseline SFRs. SFRs for each time point (8, 12, 16, and 20 post-gene delivery periods) were normalized against the baseline SFRs indicated as zero (0) post-gene delivery periods. (A) Gene delivery in pre-disease stage at 6 weeks of age. (B) Gene delivery in clinical disease stage at 14 weeks of age. Values are mean ± standard error of the mean (n = 7). *P < 0.05 rAAV2-IL27 group versus rAAV2-LacZ or saline groups by one-way analysis-of-variance test; **P < 0.01. IL-27, rAAV2-IL27-treated groups; LacZ, rAAV2-LacZ-treated groups; Saline, saline-treated groups.
Lee et al. Arthritis Research & Therapy 2012 14:R172 doi:10.1186/ar3925