Table 1

Smoking,alcohol drinkingand antibody response following pneumococcal vaccination in entire study population/different groups

All participants

(I)

RA on MTX

(II)

RA on anti-TNF as monotheraphy

(III)

RA on anti-TNF+ MTX

(IV)

SpA on anti-TNF as monotherapy

(V)

SpA on anti-TNF+MTX

(VI)

SpA on NSAID/analgesics

Number of patients at vaccination

505

85

79

89

83

83

86

Females (%)

63

79

87

78

34

53

45

CRP g/L (mean)

6.7

8.9

9.4

5.9

2.9

5.1

7.7

ESR mm/h (mean)

21.5

28.3

28.6

24.4

11.7

15.3 ( 5 15.3

19.8

Current smokers (%)

17

19

19

18

12

24

12

Ex-smokers (%)

40

39

38

45

45

39

35

Ever-smokers (%)

57.4

56.5

57.0

65.2

55.4

60.2

44.2

Smoking pack-years; mean (SD)

19.4 (14)

22.0 (13)

21.0 (15)

20.4 (14)

16.0 (13)

19.4 (13)

16.8 (13)

Current alcohol drinking (g/week) mean (SD)

9.7 (9)

13.2 (11)

8.0 (9)

10.4 (13)

12.2 (12)

8.5 (8)

11.8 (9)

IgG at vaccination (g/L)(SD)

10.4 (2.7)

9.7 (2.5)

11.8 (3.3)

11.0 (3.3)

9.9 (1.9)

9.9 (2.2)

9.9 (2.1)

IgM at vaccination (g/L)(SD)

1.3 (0.8)

1.1 (0.6)

1.7 (1.0)

1.4 (0.7)

1.3 (0.8)

1.2 (0.7)

1.0 (0.6)

IgA at vaccination (g/L)(SD)

2.7 (1.2)

2.5 (1.0)

3.3 (1.4)

2.8 (1.2)

2.7 (1.1)

2.4 (1.1)

2.5 (1.1)

Immune response (IR) for 23F (mean) ¹

3.5

2.5

3.4

2.2

4.8

3.0

6.6

Immune response (IR) ¹ for 6B (mean)

2.3

1.8

2.7

1.6

3.1

1.8

3.3

Patients with protective antibody levels for both 23F and 6B 4-6 weeks after vaccination (%)(posIR) ²

32.9

21.2

36.7

15.7

50.6

20.5

47.7

¹Immune response = ratio between post- and prevaccination antibody levels.

² Positive immune response (posIR) was defined as IR ≥2.

Roseman et al. Arthritis Research & Therapy 2012 14:R170   doi:10.1186/ar3923