Table 3

Effect of anti-NRP1^B treatment on joint inflammation and destruction in mice with collagen-induced arthritis

Joint findings, %

Treatment

Normal

Mild

Moderate

Severe

P†

PBS

20.7

5.2

32.7

41.4

anti-NRP1^B

42.1

17.5

22.9

17.5

0.0021

Values are the percentage of joints with normal appearance or exhibiting inflammation and cartilage/bone degradation graded as mild, moderate, or severe, as assessed by haematoxylin and eosin. The numbers of joints assessed were as follows: 57 in the phage-derived monoclonal antibody against neuropilin-1 (anti-NRP1^B)-treated group and 58 in the PBS-treated group.

† The absolute numbers of mice exhibiting normal, mild, moderate, and severe arthritis changes were compared, and significance versus untreated mice was analysed by chi-square test for trend.

Raatz et al. Arthritis Research & Therapy 2012 14:R169   doi:10.1186/ar3922