Synovial neovascularisation in mice with acute collagen-induced arthritis (CIA). A) Histopathological features of haematoxylin and eosin (H&E) or anti-CD31 stained serial paw sections from healthy and arthritic mice at the peak of CIA. Images show the metatarsal joints (original magnification × 40). B) Functional capillary density and C) capillary diameter in knee joint synovial tissue of mice with established CIA (n = 29) in comparison to age-matched healthy (n = 17) mice as revealed by intravital microscopy (IVM). The arthritic group included mice analysed at different time points throughout the course of CIA. Data are expressed as mean ± SEM (Mann Whitney test, *P < 0.05).
Raatz et al. Arthritis Research & Therapy 2012 14:R169 doi:10.1186/ar3922