Table 1

Bone marrow stromal cells from all three mouse strains had characteristics of mesenchymal stem cells in terms of morphology, differentiation capacity and cell surface markers.

Mouse Strain

DBA/1

FVB

BALB/c

MHC H2 Haplotype

H2^q

H2^q

H2^d

Morphology

Fibroblastic

Fibroblastic

Fibroblastic

Adipogenesis

Positive

Positive

Positive

Osteogenesis^a

(μg Ca/well)

6.9 ± 1.6

48.0 ± 0.9

11.9 ± 0.2

Chondrogenesis^a

(μg GAG/pellet)

5.6 ± 0.3

5.6 ± 0.5

5.6 ± 0.3

CD73^b

64.8

97

17.2

CD105^b

82

49.5

97.9

Sca 1^b

89.9

67.5

53

CD29

99.2

99.4

96.2

CD44

95.1

98.7

99.7

CD45^b

0.6

4

0.6

CD34^b

0.4

0.4

0.8

CD31^b

0.4

0.5

1.3

^aData represents mean ± standard deviation of triplicate assays; ^b % positive cells; GAG, glycosaminoglycan; MHC, major histocompatibility complex.

Sullivan et al. Arthritis Research & Therapy 2012 14:R167   doi:10.1186/ar3916