The effect of systemically infused MSCs on the progression of CIA in DBA/1 mice. A, Intravenous (iv) infusion of syngeneic DBA/1 MSCs at the time of booster immunization had no effect on disease progression. B, While there appeared to be some worsening of disease progression after iv delivery of partially mismatched FVB MSCs, this did not reach statistical significance. C, Systemic delivery of fully mismatched BALB/c MSCs resulted in a significant exacerbation of disease progression compared to control groups which received vehicle alone. D, Representative images of swollen hind paws ranging from normal (top image) to grossly swollen (bottom image). E, Representative image of dactylitis in a single digit. All experiments were performed with n = 12 and results are represented as mean ± standard deviation. *P <0.05, Shapiro Wilks testing for normal distribution followed by unpaired T and Mann Whitney U tests. CIA, collagen induced arthritis; MSC, mesenchymal stem cells; n, number.
Sullivan et al. Arthritis Research & Therapy 2012 14:R167 doi:10.1186/ar3916