Table 2

Side effects leading to cessation of leflunomide

Side effect

Number of patients reporting side effect


Diarrhea

8


Nausea/Vomiting

7


Elevated transaminases*

6


Shortness of breath/cough/pneumonitis

5


Dizziness/fainting

4


Rash

3


Haematological

3†


Abdominal cramps/bloating

3


Hair loss

2


Fatigue

2


9 others‡

1 each


* Elevated transaminases ranged from 2 to 30 times the upper limit of normal

† Includes one case each of oxidative haemolysis, neutropenia and leucopenia

‡ one each of muscle pain, blurred vision, facial flushing, mouth ulcers, taste disturbance, heavy/painful menstruation, peripheral neuropathy, loss of weight and headaches.

Wiese et al. Arthritis Research & Therapy 2012 14:R163   doi:10.1186/ar3911

Open Data