Table 4

Correlation of changes in IGF-1, pain, and pain threshold, and changes in cerebrospinal markers

ΔIGF-1 (serum)

ΔPain threshold

ΔPain


0.495

0.539

0.075

ΔCSF SP

P = 0.072

P = 0.038

P = 0.790

n = 14

n = 15

n = 15


-0.164

0.335

0.016

ΔCSF NGF

P = 0.558

P = 0.204

P = 0.953

n = 15

n = 16

n = 16


0.802

0.288

0.315

ΔCSF NPY

P = 0.001

P = 0.318

P = 0.273

n = 13

n = 14

n = 14


-0.165

0.225

-0.119

ΔCSF IL-6

P = 0.573

P = 0.420

P = 0.673

n = 15

n = 15

n = 15


-0.164

-0.109

0.103

ΔCSF IL-8

P = 0.558

P = 0.688

P = 0.704

n = 15

n = 16

n = 16


-0.156

-0.579

0.329

ΔCSF MMP3

P = 0.594

P = 0.024

P = 0.231

n = 14

n = 15

n = 15


Median and range (min-max) indicated. Spearmans rho(rs), two-tailed significance (P), and number of subjects (n) are presented.

Bjersing et al. Arthritis Research & Therapy 2012 14:R162   doi:10.1186/ar3902

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