Table 2

Baseline clinical variables and B-cell subsets in responders and non-responders, as determined by univariate logistic regression

Clinical variable or B-cell subset

Responders

Non-responders

OR (95% CI)

P value


Age in years, median (interquartile range)

62.9 (58.2-67.7)

60.6 (49.7-71.4)

0.99 (0.92-1.05)

0.647

sDMARD use, median (interquartile range)

2.5 (2.1-2.8)

2.4 (1.5-3.3)

0.84 (0.33-2.14)

0.956

Prior anti-TNF use, median (interquartile range)

1.1 (0.8-1.4)

1.1 (0.3-2.0)

1.02 (0.37-2.80)

0.978

ESRa, median (interquartile range)

6.1 (5.4-6.8)

5.0 (2.9-7.2)

0.74 (0.47-1.17)

0.202

Rheumatoid factor, number (percentage)

Positive

27 (90.0)

7 (100.0)

1.91 (0.43-8.32)

0.389b

Negative

3 (10.0)

0 (0.0)

B-cell subset, median (interquartile range)

Naïve cellsc

8.9 (8.6-9.3)

9.2 (8.6-9.8)

1.51 (0.56-4.11)

0.416

Post-switch memoryc

7.4 (7.1-7.6)

7.9 (7.4-8.5)

3.91 (0.93-16.45)

0.063

Plasmablastsd

3.8 (3.3-4.4)

5.2 (3.8-6.6)

2.22 (1.04-4.74)

0.040

B-cell depletion, number (percentage)

Complete

2 (6.7)

1 (14.3)

2.33 (0.18-30.10)

0.516

Incomplete

28 (93.3)

6 (85.7)


aSquare root values; bcalculated from contingency table, Pearson-Mantel-Haenszel P value; cnatural log (absolute number of cells); dnatural log (absolute number of cells + 1). anti-TNF, anti-tumor necrosis factor; CI, confidence interval; ESR, erythrocyte sedimentation rate; OR, odds ratio; sDMARD, synthetic disease-modifying anti-rheumatic drug.

Brezinschek et al. Arthritis Research & Therapy 2012 14:R161   doi:10.1186/ar3901

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