Lack of synergy between MSU and FSL-1 in the induction of IL-1β. Release of IL-1β (A), IL-6 (B) IL-8 (C) and TNFα (D)by peripheral blood mononuclear cells of patients with gout and healthy donors after having been left untreated (RPMI) or stimulated by monosodium urate monohydrate (MSU) crystals alone or in combination with fibroblast stimulation ligand-1 [FLS-1]. Asterisks denote outliers and circles denote extremes. P values indicate significant differences between respective values of patients and healthy controls by Mann-Whitney U-test. Gout patients n = 18 and healthy controls n = 12.
Mylona et al. Arthritis Research & Therapy 2012 14:R158 doi:10.1186/ar3898