Table 1

Differential diagnosis of idiopathic CD4 lymphocytopenia

Infections

HIV1,2

HTLV1, 2

Mycobacterial infections

EBV, CMV

Malignancies/hematologic conditions

Lymphoma

Aplastic anemia

Myelodysplastic syndrome

Autoimmune

Systemic lupus erythematosus

Sjögren's syndrome

Kikuchi disease

Medications

Chemotherapy and immunosuppressants

Corticosteroids

Genetic syndromes

XMEN

WHIM

Unc119 mutation

Various

Sarcoidosis

Common variable immunodeficiency


CMV, cytomegalovirus; EBV, Epstein-Barr virus; Unc119, Uncoordinated 119; WHIM, warts, hypogammaglobulinemia, infections, and myelokathexis; XMEN, X-linked magnesium deficiency with Epstein-Barr virus and neoplasia.

Zonios et al. Arthritis Research & Therapy 2012 14:222   doi:10.1186/ar4027