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Highly Accessed Review

Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair

Wei Zhang12, Jialin Chen12, Shufang Zhang12 and Hong Wei Ouyang123*

Author Affiliations

1 Center for for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China 310058

2 Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, Hangzhou, China 310000

3 Department of Sports Medicine, School of Medicine, Zhejiang University, Hangzhou, China 310058

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Arthritis Research & Therapy 2012, 14:221  doi:10.1186/ar4025

Published: 31 August 2012

Abstract

Cartilage repair tissue is usually accompanied by chondrocyte hypertrophy and osseous overgrowths, and a role for parathyroid hormone-related protein (PTHrP) in inhibiting chondrocytes from hypertrophic differentiation during the process of endochondral ossification has been demonstrated. However, application of PTHrP in cartilage repair has not been extensively considered. This review systemically summarizes for the first time the inhibitory function of PTHrP on chondrocyte hypertrophy in articular cartilage and during the process of endochondral ossification, as well as the process of mesenchymal stem cell chondrogenic differentiation. Based on the literature review, the strategy of using PTHrP for articular cartilage repair is suggested, which is instructive for clinical treatment of cartilage injuries as well as osteoarthritis.