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Highly Accessed Editorial

Inflammation, endothelial function and atherosclerosis in rheumatoid arthritis

Miguel A González-Gay1* and Carlos González-Juanatey2

Author affiliations

1 Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Avenida de Valdecilla s/n, E-39008, Santander, Spain

2 Cardiology Division, Hospital Lucus Augusti, c/ San Cibrao s/n 27003 Lugo, Spain

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Citation and License

Arthritis Research & Therapy 2012, 14:122  doi:10.1186/ar3891


See related research by Sandoo et al., http://arthritis-research.com/content/14/3/R117

Published: 19 July 2012

Abstract

Different techniques have proven to be useful in determining the presence of subclinical cardiovascular disease in patients with rheumatoid arthritis (RA). Doppler imaging with iontophoresis of acetylcholine and flow-mediated, endothelium-dependent vasodilation give information on endothelial dysfunction, an early step in the atherogenesis process. However, there is no good correlation between these two surrogate markers of cardiovascular disease in RA. A single determination of routine laboratory markers of inflammation does not seem to relate to endothelial function in RA. Further research is needed to determine whether microvascular endothelial function is a better predictor of cardiovascular outcome than macrovascular endothelial function in patients with RA.