Cytokine concentrations in ocular fluids from uveitis patients with Behçet's disease during infliximab treatment. The levels of cytokines such as IFN-γ, IL-2, IL-4, IL-10, TNF-α, IL-6, and IL-17 were evaluated by ELISA or CBA. Ocular fluid samples from patients who had Behçet's disease (BD) with active uveitis (n = 6) or inactive uveitis (n = 4; no signs or symptoms of uveitis at the remission stage without treatment) were used for the assay. We also collected ocular fluid samples from BD patients receiving infliximab (IFX, n = 8). The controls consisted of the aqueous humor of patients with age-related cataracts (n = 3) and the vitreous fluid of patients with idiopathic macular holes (n = 3). P value indicates active uveitis group (active UVE) vs. infliximab group (IFX treatment). CBA, cytometric beads array; n.s., not significant.
Sugita et al. Arthritis Research & Therapy 2012 14:R99 doi:10.1186/ar3824