Table 2

Pooled analysis of CD40LG polymorphisms in female SSc patients and controls

SNP

Change

Samples set

N

Minor allele,

no. (frequency)

P value

OR [95% CI]

P_BD


rs3092952

G/A

Controls

1,795

655 (0.176)

SSc

2,082

735 (0.186)

0.440

0.96 [0.85-1.07]

0.18

lcSSc

1,446

515 (0.188)

0.592

0.97 [0.85-1.10]

0.12

dcSSc

635

219 (0.179)

0.307

0.92 [0.77-1.09]

0.73

ACA +

924

338 (0.195)

0.978

1.00 [0.87-1.16]

0.06

ATA +

533

184 (0.188)

0.375

0.92 [0.77-1.11]

0.50

Pulmonary fibrosis

542

198 (0.173)

0.735

0.97 [0.81-1.16]

0.41


rs3092920

T/G

Controls

1,789

376 (0.107)

SSc

2,104

426 (0.105)

0.565

0.96 [0.83-1.11]

0.89

lcSSc

1,456

310 (0.112)

0.929

1.01 [0.86-1.18]

0.97

dcSSc

647

116 (0.091)

0.120

0.84 [0.67-1.05]

0.36

ACA +

939

201 (0.111)

0.924

1.01 [0.84-1.21]

0.48

ATA +

541

106 (0.103)

0.434

0.91 [0.73-1.15]

0.86

Pulmonary fibrosis

549

124 (0.106)

0.657

1.05 [0.84-1.31]

0.55


Controls are used as reference for all comparisons. All P values have been calculated for the allelic model by using the Mantel-Haenszel test under fixed effect. P_BD, P value by the Breslow-Day method.

Teruel et al. Arthritis Research & Therapy 2012 14:R154   doi:10.1186/ar3890

Open Data