Table 2 |
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|
Pooled analysis of CD40LG polymorphisms in female SSc patients and controls |
|||||||
|
SNP |
Change |
Samples set |
N |
Minor allele, no. (frequency) |
P value |
OR [95% CI] |
P_BD |
|
|
|||||||
|
rs3092952 |
G/A |
Controls |
1,795 |
655 (0.176) |
|||
|
SSc |
2,082 |
735 (0.186) |
0.440 |
0.96 [0.85-1.07] |
0.18 |
||
|
lcSSc |
1,446 |
515 (0.188) |
0.592 |
0.97 [0.85-1.10] |
0.12 |
||
|
dcSSc |
635 |
219 (0.179) |
0.307 |
0.92 [0.77-1.09] |
0.73 |
||
|
ACA + |
924 |
338 (0.195) |
0.978 |
1.00 [0.87-1.16] |
0.06 |
||
|
ATA + |
533 |
184 (0.188) |
0.375 |
0.92 [0.77-1.11] |
0.50 |
||
|
Pulmonary fibrosis |
542 |
198 (0.173) |
0.735 |
0.97 [0.81-1.16] |
0.41 |
||
|
|
|||||||
|
rs3092920 |
T/G |
Controls |
1,789 |
376 (0.107) |
|||
|
SSc |
2,104 |
426 (0.105) |
0.565 |
0.96 [0.83-1.11] |
0.89 |
||
|
lcSSc |
1,456 |
310 (0.112) |
0.929 |
1.01 [0.86-1.18] |
0.97 |
||
|
dcSSc |
647 |
116 (0.091) |
0.120 |
0.84 [0.67-1.05] |
0.36 |
||
|
ACA + |
939 |
201 (0.111) |
0.924 |
1.01 [0.84-1.21] |
0.48 |
||
|
ATA + |
541 |
106 (0.103) |
0.434 |
0.91 [0.73-1.15] |
0.86 |
||
|
Pulmonary fibrosis |
549 |
124 (0.106) |
0.657 |
1.05 [0.84-1.31] |
0.55 |
||
|
|
|||||||
|
Controls are used as reference for all comparisons. All P values have been calculated for the allelic model by using the Mantel-Haenszel test under fixed effect. P_BD, P value by the Breslow-Day method. |
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|
Teruel et al. Arthritis Research & Therapy 2012 14:R154 doi:10.1186/ar3890 |
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