Table 1 |
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|
Pooled analysis of CD40 polymorphisms |
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|
SNP |
Change |
Samples set |
N |
Minor allele, no. (frequency) |
P value |
OR [95% CI] |
P-BD |
|
|
|||||||
|
rs1883832 |
T/C |
Controls |
3,138 |
1,427 (0.277) |
|||
|
SSc |
2,605 |
1,424 (0.274) |
0.610 |
1.02 [0.94-1.11] |
0.904 |
||
|
lcSSc |
1,758 |
987 (0.276) |
0.246 |
1.06 [0.96-1.16] |
0.496 |
||
|
dcSSc |
860 |
451 (0.271) |
0.683 |
0.97 [0.86-1.10] |
0.446 |
||
|
ACA + |
1,077 |
592 (0.261) |
0.879 |
1.01 [0.90-1.13] |
0.355 |
||
|
ATA + |
716 |
416 (0.293) |
0.108 |
1.11 [0.98-1.26] |
0.946 |
||
|
Pulmonary fibrosis |
702 |
394 (0.278) |
0.433 |
1.05 [0.92-1.20] |
0.802 |
||
|
|
|||||||
|
rs4810485 |
G/T |
Controls |
3,122 |
1,652 (0.272) |
|||
|
SSc |
2,560 |
1,388 (0.274) |
0.420 |
1.04 [0.95-1.13] |
0.935 |
||
|
lcSSc |
1,736 |
967 (0.277) |
0.155 |
1.07 [0.97-1.18] |
0.481 |
||
|
dcSSc |
839 |
436 (0.269) |
0.817 |
0.99 [0.87-1.12] |
0.600 |
||
|
ACA + |
1,071 |
580 (0.257) |
0.844 |
1.01 [0.90-1.13] |
0.399 |
||
|
ATA + |
699 |
402 (0.292) |
0.080 |
1.12 [0.99-1.28] |
0.890 |
||
|
Pulmonary fibrosis |
682 |
375 (0.272) |
0.483 |
1.05 [0.92-1.20] |
0.605 |
||
|
|
|||||||
|
rs1535045 |
T/C |
Controls |
3,147 |
1,595 (0.247) |
|||
|
SSc |
2,585 |
1,272 (0.243) |
0.275 |
0.95 [0.88-1.04] |
0.560 |
||
|
lcSSc |
1,749 |
860 (0.251) |
0.375 |
0.96 [0.87-1.05] |
0.334 |
||
|
dcSSc |
850 |
411 (0.228) |
0.275 |
0.93 [0.82-1.06] |
0.746 |
||
|
ACA + |
1,075 |
525 (0.241) |
0.348 |
0.95 [0.84-1.06] |
0.844 |
||
|
ATA + |
707 |
369 (0.264) |
0.669 |
1.03 [0.90-1.18] |
0.640 |
||
|
Pulmonary fibrosis |
696 |
340 (0.250) |
0.396 |
0.94 [0.82-1.08] |
0.028 |
||
|
|
|||||||
|
Controls are used as reference for all comparisons. All P values have been calculated for the allelic model by using the Mantel-Haenszel test under fixed effect. P_BD, P value by the Breslow-Day method. |
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|
Teruel et al. Arthritis Research & Therapy 2012 14:R154 doi:10.1186/ar3890 |
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