Table 1

Pooled analysis of CD40 polymorphisms

SNP

Change

Samples set

N

Minor allele,

no. (frequency)

P value

OR [95% CI]

P-BD


rs1883832

T/C

Controls

3,138

1,427 (0.277)

SSc

2,605

1,424 (0.274)

0.610

1.02 [0.94-1.11]

0.904

lcSSc

1,758

987 (0.276)

0.246

1.06 [0.96-1.16]

0.496

dcSSc

860

451 (0.271)

0.683

0.97 [0.86-1.10]

0.446

ACA +

1,077

592 (0.261)

0.879

1.01 [0.90-1.13]

0.355

ATA +

716

416 (0.293)

0.108

1.11 [0.98-1.26]

0.946

Pulmonary fibrosis

702

394 (0.278)

0.433

1.05 [0.92-1.20]

0.802


rs4810485

G/T

Controls

3,122

1,652 (0.272)

SSc

2,560

1,388 (0.274)

0.420

1.04 [0.95-1.13]

0.935

lcSSc

1,736

967 (0.277)

0.155

1.07 [0.97-1.18]

0.481

dcSSc

839

436 (0.269)

0.817

0.99 [0.87-1.12]

0.600

ACA +

1,071

580 (0.257)

0.844

1.01 [0.90-1.13]

0.399

ATA +

699

402 (0.292)

0.080

1.12 [0.99-1.28]

0.890

Pulmonary fibrosis

682

375 (0.272)

0.483

1.05 [0.92-1.20]

0.605


rs1535045

T/C

Controls

3,147

1,595 (0.247)

SSc

2,585

1,272 (0.243)

0.275

0.95 [0.88-1.04]

0.560

lcSSc

1,749

860 (0.251)

0.375

0.96 [0.87-1.05]

0.334

dcSSc

850

411 (0.228)

0.275

0.93 [0.82-1.06]

0.746

ACA +

1,075

525 (0.241)

0.348

0.95 [0.84-1.06]

0.844

ATA +

707

369 (0.264)

0.669

1.03 [0.90-1.18]

0.640

Pulmonary fibrosis

696

340 (0.250)

0.396

0.94 [0.82-1.08]

0.028


Controls are used as reference for all comparisons. All P values have been calculated for the allelic model by using the Mantel-Haenszel test under fixed effect. P_BD, P value by the Breslow-Day method.

Teruel et al. Arthritis Research & Therapy 2012 14:R154   doi:10.1186/ar3890

Open Data