H & E sections of Chlamydia-injected knee joints. Panel A and B knee joints of NM-treated rats. Panel C and D knee joints of non-treated controls. In Panels A and B, there are moderate infiltrations of inflammatory cells into the synovium. However, the synovial space is clear and a considerable amount of the fatty tissues remains. The cartilage surfaces are mostly intact. On the other hand, in Panels C and D, inflammation is extensive, the whole architecture of the joints was destroyed. Cartilage tissues had been totally eroded away and the invading panus has entered the bone marrow space. Panel D also shows an area of early focus of necrosis. Original photomicrographs taken at 10× magnification. NM, nafamostat mesylate.
Inman and Chiu Arthritis Research & Therapy 2012 14:R150 doi:10.1186/ar3886