Open Access Research article

RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis

Maria J Martínez-Calatrava, Ivan Prieto-Potín, Jorge A Roman-Blas, Lidia Tardio, Raquel Largo and Gabriel Herrero-Beaumont*

Author Affiliations

Bone and Joint Research Unit, Service of Rheumatology, IIS Fundación Jiménez D237;az, Universidad Autónoma, Av. Reyes Católicos 2, 28040, Madrid, Spain

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Arthritis Research & Therapy 2012, 14:R149  doi:10.1186/ar3884

Published: 18 June 2012

Additional files

Additional file 1:

Relationships between articular cartilage parameters and subchondral bone mineral density (BMD). Figure S1 in Additional file 1: A figure showing Spearman correlation between cartilage damage and subchondral BMD. Figure S2 in Additional file 1: A figure showing Spearman correlation between receptor activator nuclear factor-kappaB ligand (RANKL) protein expression in articular cartilage and subchondral BMD. Figure S3 in Additional file 1: A figure showing Spearman correlation between RANKL/osteoprotegerin (OPG) ratio in articular cartilage and subchondral BMD.

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Additional file 2:

Figures showing the receptor activator nuclear factor-kappaB ligand (RANKL) distribution pattern in cartilage. Figure S1 in Additional file 2: A figure showing extracelullar expression of RANKL in the rabbits with antigen-induced arthritis (AIA). Figure S2 in Additional file 2: A figure showing negative control of RANKL expression in the same area (original magnifications ×400).

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Open Data