TLR-9 expression in B cells is reduced by sema3A. The co-culture of ODN-CpG stimulated B cells from SLE patients with sema3A reduced their TLR-9 expression by almost 50%. CpG-ODN, cytosine-phosphodiester-guanine oligodeoxynucleotides; sema3A, semaphorin 3A; SLE, systemic lupus erythematosis; TLR-9, Toll-like receptor 9.
Vadasz et al. Arthritis Research & Therapy 2012 14:R146 doi:10.1186/ar3881