Clinical correlations. (A) demonstrates the inverse correlation between sema3A serum levels in SLE patients and their SLEDAI score (R = -0.89, P < 0.0001). (B) expresses the association between sema3A serum level and kidney involvement. As is shown, serum levels higher than 50 ng/ml are associated with a lower rate of kidney involvement, and those with higher than 50 ng/ml are associated with increased rate of renal damage. (C) shows the association between decreased serum sema3A levels and the presence of anti-cardiolipin antibodies positivity. Sema3A, semaphorin 3A; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.
Vadasz et al. Arthritis Research & Therapy 2012 14:R146 doi:10.1186/ar3881