Table 2

Effect of anti-TNFα treatment on clinical and metabolic profile in rheumatoid arthritis RA patients with low and high baseline insulin resistance*

Insulin resistance


Low (n = 31)

P value

High (n = 30)

P value


DAS28

-0.52 (-1.20, 0.16)

0.127

-0.57 (-1.01, -0.13)

0.013

HAQ

-0.23 (-0.42, -0.05)

0.018

-0.26 (-0.45, -0.06)

0.012

ESR

-3.04 (-15.3, 9.20)

0.611

-1.04 (-7.91, 5.84)

0.760

C-reactive protein #

-0.69 (-1.91, 0.53)

0.147

-0.83 (-1.72, 0.05)

0.007

TC

-5.92 (-20.0, 8.21)

0.395

8.63 (-6.53, 23.8)

0.253

Triglycerides

12.3 (-16.7, 41.3)

0.390

-24.5 (-47.7, -1.31)

0.039

HDL-C

0.75 (-3.25, 4.75)

0.701

4.21 (0.65, 7.78)

0.022

LDL-C

-9.78 (-20.2, 0.64)

0.065

9.15 (-3.94, 22.2)

0.163

TC/HDL-C

-0.08 (-0.35, 0.18)

0.511

-0.12 (-0.44, 0.19)

0.421

LDL-C/HDL-C

-0.14 (-0.31, 0.03)

0.110

0.01 (-0.25, 0.27)

0.929

Lpa #

-4.38 (-9.31, 0.55)

0.147

0.25 (-7.72, 8.22)

0.200

apoA

-6.12 (-17.3, 5.03)

0.262

5.64 (-3.94, 15.2)

0.236

apoB

-2.99 (-13.0, 6.99)

0.534

2.09 (-4.81, 8.99)

0.537

Homocysteine #

-2.66 (-5.88, 0.57)

0.122

2.53 (-0.35, 5.41)

0.039

FBG

1.08 (-1.02, 1.18)

0.117

-19.7 (-34.8, -4.61)

0.016

HOMA-IR #

1.87 (-0.34, 4.09)

0.197

-5.68 (-8.86, -2.50)

< 0.001

HOMA-B #

-130 (-375, 116)

0.446

-148 (-244, -46)

0.001

QUICKI #

-0.01 (-0.03, 0.01)

0.264

0.07 (0.04, 0.09)

< 0.001

Insulin #

5.80 (-1.12, 12.7)

0.301

-21.7 (-33.8, -9.62)

< 0.001


Values are the mean (95% confidence interval)

* The median Homeostasis Model Assessment for insulin resistance (HOMA-IR) value at baseline was used to assign patients into low (HOMA-IR ≤ 3.18, n = 31) or high (HOMA-IR > 3.18, n = 30) insulin resistance group

† Paired t-test for comparison of values between baseline and after 12 weeks of anti-TNF treatment

# Statistical comparisons were performed using log transformed values

DAS28: disease activity score of 28 joints; HAQ: health assessment questionnaire; ESR: erythrocyte sedimentation rate; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; Lpa: lipoprotein a; apo: apolipoprotein; FBG: fasting blood glucose; QUICKI: Quantitative Insulin Sensitivity Check Index.

Stagakis et al. Arthritis Research & Therapy 2012 14:R141   doi:10.1186/ar3874

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