Table 2 |
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|
Effect of anti-TNFα treatment on clinical and metabolic profile in rheumatoid arthritis RA patients with low and high baseline insulin resistance* |
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|
Insulin resistance |
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|
|
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|
Low (n = 31) |
P value† |
High (n = 30) |
P value |
|
|
|
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|
DAS28 |
-0.52 (-1.20, 0.16) |
0.127 |
-0.57 (-1.01, -0.13) |
0.013 |
|
HAQ |
-0.23 (-0.42, -0.05) |
0.018 |
-0.26 (-0.45, -0.06) |
0.012 |
|
ESR |
-3.04 (-15.3, 9.20) |
0.611 |
-1.04 (-7.91, 5.84) |
0.760 |
|
C-reactive protein # |
-0.69 (-1.91, 0.53) |
0.147 |
-0.83 (-1.72, 0.05) |
0.007 |
|
TC |
-5.92 (-20.0, 8.21) |
0.395 |
8.63 (-6.53, 23.8) |
0.253 |
|
Triglycerides |
12.3 (-16.7, 41.3) |
0.390 |
-24.5 (-47.7, -1.31) |
0.039 |
|
HDL-C |
0.75 (-3.25, 4.75) |
0.701 |
4.21 (0.65, 7.78) |
0.022 |
|
LDL-C |
-9.78 (-20.2, 0.64) |
0.065 |
9.15 (-3.94, 22.2) |
0.163 |
|
TC/HDL-C |
-0.08 (-0.35, 0.18) |
0.511 |
-0.12 (-0.44, 0.19) |
0.421 |
|
LDL-C/HDL-C |
-0.14 (-0.31, 0.03) |
0.110 |
0.01 (-0.25, 0.27) |
0.929 |
|
Lpa # |
-4.38 (-9.31, 0.55) |
0.147 |
0.25 (-7.72, 8.22) |
0.200 |
|
apoA |
-6.12 (-17.3, 5.03) |
0.262 |
5.64 (-3.94, 15.2) |
0.236 |
|
apoB |
-2.99 (-13.0, 6.99) |
0.534 |
2.09 (-4.81, 8.99) |
0.537 |
|
Homocysteine # |
-2.66 (-5.88, 0.57) |
0.122 |
2.53 (-0.35, 5.41) |
0.039 |
|
FBG |
1.08 (-1.02, 1.18) |
0.117 |
-19.7 (-34.8, -4.61) |
0.016 |
|
HOMA-IR # |
1.87 (-0.34, 4.09) |
0.197 |
-5.68 (-8.86, -2.50) |
< 0.001 |
|
HOMA-B # |
-130 (-375, 116) |
0.446 |
-148 (-244, -46) |
0.001 |
|
QUICKI # |
-0.01 (-0.03, 0.01) |
0.264 |
0.07 (0.04, 0.09) |
< 0.001 |
|
Insulin # |
5.80 (-1.12, 12.7) |
0.301 |
-21.7 (-33.8, -9.62) |
< 0.001 |
|
|
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|
Values are the mean (95% confidence interval) * The median Homeostasis Model Assessment for insulin resistance (HOMA-IR) value at baseline was used to assign patients into low (HOMA-IR ≤ 3.18, n = 31) or high (HOMA-IR > 3.18, n = 30) insulin resistance group † Paired t-test for comparison of values between baseline and after 12 weeks of anti-TNF treatment # Statistical comparisons were performed using log transformed values DAS28: disease activity score of 28 joints; HAQ: health assessment questionnaire; ESR: erythrocyte sedimentation rate; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; Lpa: lipoprotein a; apo: apolipoprotein; FBG: fasting blood glucose; QUICKI: Quantitative Insulin Sensitivity Check Index. |
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|
Stagakis et al. Arthritis Research & Therapy 2012 14:R141 doi:10.1186/ar3874 |
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