Table 3

Univariate associations between ADORA3 rs1544224 and disease activity.

Variable

Genotypea

Allelic P value

11

12

22


SJC (28)

2.9 ± 3.4

2.7 ± 3.9

3.0 ± 3.0

0.89

123 (54.7%)

84 (37.6%)

18 (8.2%)

TJC (28)

2.5 ± 3.5

2.4 ± 3.9

1.7 ± 2.3

0.65

123 (54.7%)

84 (37.6%)

18 (8.2%)

DAS28

2.9 ± 1.2

2.9 ± 1.3

2.9 ± 1.1

0.99

123 (54.7%)

84 (37.6%)

18 (8.2%)

CRP

1.2 ± 2.1

1.1 ± 1.4

1.1 ± 0.9

0.98

105 (46.7%)

66 (29.3%)

16 (7.1%)

Physicians global

23.5 ± 19.5

22.0 ± 19.8

15.5 ± 12.7

0.26

123 (54.7%)

84 (37.6%)

18 (8.2%)

Physicians response to MTX

22.9 ± 18.9

22.2 ± 20.7

14.5 ± 13.6

0.23

118 (52.4%)

71 (9.3%)

18 (8.2%)

Pain VAS

23.6 ± 22.8

22.8 ± 23.9

20.1 ± 22.9

0.83

123 (54.7%)

84 (37.6%)

18 (8.2%)

Patient global

26.4 ± 21.9

27.6 ± 24.6

23.7 ± 17.1

0.79

123 (54.7%)

84 (37.6%)

18 (8.2%)

mHAQ

0.42 ± 0.49

0.42 ± 0.45

0.37 ± 0.47

0.89

123 (54.7%)

84 (37.6%)

18 (8.2%)


a1 = major allele, 2 = minor allele of rs1544224. Top row mean ± SD, bottom row number of patients. CRP, C-reactive protein; DAS28, disease activity score in 28 joints; HAQ, Health Assessment Questionnaire; MTX, methotrexate; SD, standard deviation; SJC, swollen joint count; TJC, tender joint count; VAS, visual analog scale.

Stamp et al. Arthritis Research & Therapy 2012 14:R138   doi:10.1186/ar3871

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