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Open Access Research article

Adenosine receptor expression in rheumatoid synovium: a basis for methotrexate action

Lisa K Stamp1*, Jody Hazlett2, Rebecca L Roberts3, Christopher Frampton1, John Highton4 and Paul A Hessian2

Author Affiliations

1 Department of Medicine, University of Otago, Christchurch, 2 Riccarton Ave, Christchurch 8014, New Zealand

2 Department of Physiology, University of Otago, Great King Street, Dunedin 9016, New Zealand

3 Department of Biochemistry, University of Otago, Great King Street, Dunedin 9016, New Zealand

4 Department of Medicine, University of Otago, Great King Street, Dunedin 9016, New Zealand

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Arthritis Research & Therapy 2012, 14:R138  doi:10.1186/ar3871

Published: 8 June 2012

Additional files

Additional file 1:

Supplementary Table S1. Primers used for amplification, sequencing, and genotyping of ADORA3.

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Additional file 2:

Supplementary Figure 1. Genomic organization of ADORA3. The ADORA3 gene is localized to chromosome 1p21-p13 and comprises two exons separated by a single large intron (not shown to scale). Untranslated regions (UTRs) and the open reading frame (ORF) are represented by light and dark grey rectangles, respectively. Location of single nucleotide polymorphisms (SNPs) found by sequencing 15 RA patients with low disease activity (DAS28 ≤ 3.2) and 15 RA patients with high disease activity (DAS28 > 3.2) are indicated by vertical arrows.

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Additional file 3:

Supplementary Table S2. Univariate associations between ADORA3 rs1544224 and MTX adverse effects. Top row number of patients and bottom row percentage.

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