Table 3

Unadjusted mean leptin by sex for hand osteoarthritis status and potential confounders in NHANES III

Male

Female

n

Mean^a (95% CI)

n

Mean^a (95% CI)

Overall

510

7.66 (7.11, 8.21)

546

19.24 (17.19, 21.29)

Hand OA status

Symptomatic hand OA

36

7.38 (5.31, 9.46)

54

21.55 (17.08, 26.02)

Asymptomatic hand OA

159

6.69 (5.19, 8.18)

217

17.09 (15.00, 19.18)

No hand OA

315

8.22 (7.47, 8.97)

275

20.77 (18.01, 23.53)

Age

60 to 69 years

255

7.53 (6.83, 8.22)

233

21.43 (18.73, 24.13)

70 to 79 years

147

7.88 (6.47, 9.29)

197

17.60 (14.47, 20.73)

80+ years

108

7.66 (6.24, 9.07)

116

16.00 (12.73, 19.28)

Race/ethnicity

Non-Hispanic white

273

7.62 (7.06, 8.17)

326

18.73 (16.52, 20.95)

Non-Hispanic black

89

7.30 (5.61, 8.99)

101

24.39 (21.52, 27.25)

Hispanic

139

8.74 (6.24, 11.25)

115

19.34 (13.94, 24.74)

Other

9

7.42 (6.31, 8.53)

4

19.83 (-2.88, 42.54)

BMI status

Normal (BMI < 25 kg/m²)

183

5.00 (4.30, 5.70)

199

11.54 (10.30, 12.77)

Overweight (25 ≤ BMI < 30 kg/m²)

217

7.73 (6.75, 8.70)

179

19.65 (17.68, 21.63)

Obese (BMI ≥ 30 kg/m²)

90

13.03 (11.03, 15.03)

118

34.55 (31.22, 37.88)

Radiographic knee OA

Yes

132

8.99 (7.53, 10.45)

211

23.31 (19.55, 27.08)

No

357

7.09 (6.59, 7.60)

315

16.93 (14.99, 18.87)

Diabetes

Yes

64

8.69 (7.10, 10.27)

72

20.62 (16.47, 24.76)

No

445

7.55 (7.02, 8.08)

473

19.1 (17.13, 21.08)

Total cholesterol

Desirable (< 200)

201

7.24 (6.33, 8.14)

136

14.87 (12.01, 17.73)

Borderline high (200 to 239)

193

7.36 (6.66, 8.07)

197

18.99 (16.40, 21.58)

High (≥ 240)

113

8.18 (6.92, 9.44)

204

22.20 (18.99, 25.41)

BMI, body mass index; CI, confidence interval; OA, osteoarthritis. ^aMeans are weighted using Third National Health and Nutrition Examination Survey (NHANES III) sampling weights.

Massengale et al. Arthritis Research & Therapy 2012 14:R132   doi:10.1186/ar3864