Figure 1.

Radiographs and histological aspect of hind limbs at Day 21 after the onset of arthritis. Experiments were performed in controls rats (A, D), AIA rats (B, E) and nor-NOHA treated rats (C, F). On radiographs, both AIA and treated AIA rats exhibited a thickening of the soft tissues of the ankle and foot as well as a joint destruction and periosteal tissue neoformation. Histological slices were stained with HES (enlargement × 20). A severe joint destruction associated to synovial proliferation was present in AIA and treated AIA rats.