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Open Access Research article

Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis

Clément Prati12*, Alain Berthelot1, Bernadette Kantelip3, Daniel Wendling24 and Céline Demougeot1

Author Affiliations

1 EA 4267 Fonctions et Dysfonctions epithéliales, University of Franche Comté, 19 rue Ambroise Paré, 25030 Besançon, France

2 Department of Rheumatology, University Hospital Jean Minjoz, 3 bd Fleming, 25000 Besançon, France

3 Department of Pathologic Anatomy, University Hospital Jean Minjoz, 3 bd Fleming, 25000 Besançon, France

4 EA 4266 Agents pathogènes et inflammation, University of Franche Comté, 2 place St Jacques, 2503 Besançon, France

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Arthritis Research & Therapy 2012, 14:R130  doi:10.1186/ar3860

Published: 30 May 2012

Additional files

Additional file 1:

Time-course of clinical arthritic score in AIA and nor-NOHA-treated AIA rats. AIA rats were monitored seven days per week in a blinded fashion for clinical signs of arthritis. Day 0 = day of injection with Mycobacterium butyricum. The nor-NOHA treatment was started with the first clinical signs of arthritis. n = 20 rats per group. NS, Non-significant.

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Additional file 2:

Regression analysis between plasma VEGF and endothelial dysfunction. A significant positive correlation was found between plasma VEGF levels and endothelial dysfunction as attested by the negative correlation identified between the Emax of Ach and the plasma VEGF levels of control, AIA and nor-NOHA-treated AIA rats (n = 8 rats per group).

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