Research article
Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis
1 Haywood Rheumatology Centre, University Hospital of North Staffordshire, Stoke-on-Trent ST6 7AG, UK
2 Institute of Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK
3 Royal National Hospital for Rheumatic Diseases, Bath BA1 1RL, UK
4 Department of Rheumatology, Southmead Hospital, Bristol BS10 5NB, UK
5 Department of Rheumatology, University Hospital of North Durham, Durham DH1 5TW, UK
Arthritis Research & Therapy 2012, 14:R127 doi:10.1186/ar3857
Published: 28 May 2012Additional files
Additional file 1:
Table S1 presenting correlations between clinical measures and biomarkers in ankylosing spondylitis patients at baseline.
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Additional file 2:
Table S2 presenting correlations between clinical measures and MMP-3 and MMP-8 levels measured by ELISA in ankylosing spondylitis patients at baseline.
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Additional file 3:
Table S3 presenting alternative multiple regression models showing variables associated with the BASDAI and BAS-G at baseline.
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Additional file 4:
Table S4 presenting levels of individual biomarkers comprising principal component 3 stratified by pack-year category.
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Additional file 5:
Table S5 presenting a comparison of MMP levels in patient clusters with low or high MMP levels as selected by hierarchical cluster analysis.
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