Open Access Research article

Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis

Derek L Mattey12*, Jonathan C Packham1, Nicola B Nixon1, Lucy Coates3, Paul Creamer4, Sarah Hailwood5, Gordon J Taylor3 and Ashok K Bhalla3

Author Affiliations

1 Haywood Rheumatology Centre, University Hospital of North Staffordshire, Stoke-on-Trent ST6 7AG, UK

2 Institute of Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK

3 Royal National Hospital for Rheumatic Diseases, Bath BA1 1RL, UK

4 Department of Rheumatology, Southmead Hospital, Bristol BS10 5NB, UK

5 Department of Rheumatology, University Hospital of North Durham, Durham DH1 5TW, UK

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Arthritis Research & Therapy 2012, 14:R127  doi:10.1186/ar3857

Published: 28 May 2012

Additional files

Additional file 1:

Table S1 presenting correlations between clinical measures and biomarkers in ankylosing spondylitis patients at baseline.

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Additional file 2:

Table S2 presenting correlations between clinical measures and MMP-3 and MMP-8 levels measured by ELISA in ankylosing spondylitis patients at baseline.

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Additional file 3:

Table S3 presenting alternative multiple regression models showing variables associated with the BASDAI and BAS-G at baseline.

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Additional file 4:

Table S4 presenting levels of individual biomarkers comprising principal component 3 stratified by pack-year category.

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Additional file 5:

Table S5 presenting a comparison of MMP levels in patient clusters with low or high MMP levels as selected by hierarchical cluster analysis.

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