Table 5

Haplotype analysis of ERAP 1 SNPs in 797 AS patients and 1150 normal controls.

Associated haplotypes

Frequency

EM algorithm*

Logistic regression

Logistic regression

(rs27037 + rs27980 + rs27044)

AS

Normal

P -value

P -value

OR (95% CI)

(sex adjusted)

P -value

OR (95% CI)


GCC

0.085

0.119

9 × 10-3

7 × 10-4

0.69 (0.55-0.85)

1.9 × 10-3

0.69 (0.55-0.87)

TAG

0.008

0.012

2.6 × 10-3

3.9 × 10-3

0.21 (0.07-0.61)

4.3 × 10-3

0.21 (0.07-0.61)

TCG

0.475

0.399

<0.00001

<0.00001

1.36 (1.12-1.55)

<0.00001

1.38 (1.12-1.58)


*The p-values for the estimated haplotypes were generated from 10,000 permutations.

Wang et al. Arthritis Research & Therapy 2012 14:R125   doi:10.1186/ar3855

Open Data