Table 4

ERAP1 SNP analyses in normal controls and AS patients positive and negative for HLA-B27

SNP

/Group

RA

/RAF

Genotype

/Frequency

Trend test P**

P

Genotype analysis

OR (95% CI)

P

Allelic analysis

OR (95% CI)


rs27037

T

GG

GT

TT

GT + TT vs. GG

T vs. G

HLA-B27 + (N = 738)

0.488

0.245

0.534

0.221

0.042

5.6 × 10-3

2.17 (1.26-3.76)

0.038

1.50 (1.02-2.21)

HLA-B27 - (N = 58)

0.388

0.414

0.397

0.190

Adjusted for syndesmophyte+*

0.057

9.1 × 10-3

2.10 (1.20-3.66)

0.056

1.46(0.99-2.16)

rs27980

C

AA

AC

CC

AC + CC vs. AA

C vs. A

HLA-B27 + (N = 739)

0.578

0.165

0.514

0.321

0.172

0.034

1.93 (1.05-3.54)

0.147

1.32 (0.91-1.93)

HLA-B27 - (N = 58)

0.509

0.276

0.431

0.293

Adjusted for syndesmophyte+

0.229

0.056

1.61 (0.99-3.38)

0.217

1.27 (0.87-1.86)

rs27044

G

CC

CG

GG

CG + GG vs. CC

G vs. C

HLA-B27 + (N = 738)

0.580

0.163

0.515

0.323

6.3 × 10-3

7 × 10-4

2.71 (1.53-4.82)

5.8 × 10-3

1.70 (1.16-2.49)

HLA-B27 - (N = 58)

0.448

0.345

0.414

0.241

Adjusted for syndesmophyte+

0.010

2.7 × 10-3

2.45 (1.36-4.39)

0.011

1.64 (1.12-2.42)

rs30187

T

CC

CT

TT

CT + TT vs. CC

T vs. C

HLA-B27 + (N = 739)

0.589

0.156

0.510

0.334

6.1 × 10-3

4 × 10-4

2.86 (1.61-5.09)

5.4 × 10-3

1.71 (1.17-2.49)

HLA-B27 - (N = 58)

0.457

0.345

0.397

0.259

Adjusted for syndesmophyte+

0.011

1.6 × 10-3

2.56 (1.43-4.61)

8.5 × 10-3

1.67 (1.14-2.45)


RA: Risk allele. RAF: Risk allele frequency. * Cochran -Mantel -Haenszel tests for ERAP1 SNP and HLA-B27 associations, adjusted by syndesmophyte formation. ** The Trend test p-values were generated from 100,000 permutations. Sydesmophyte +: syndesmophyte formation positive

Wang et al. Arthritis Research & Therapy 2012 14:R125   doi:10.1186/ar3855

Open Data