Table 3 |
|||||||||
|
ERAP1 SNP analyses in normal controls and AS patients positive and negative for syndesmophyte |
|||||||||
|
SNP /Group |
RA /RAF |
Genotype /Frequency |
Trend test P** |
Genotype analysis |
Allelic analysis |
||||
|
P |
OR (95% CI) |
P |
OR (95% CI) |
||||||
|
|
|||||||||
|
rs27037 |
T |
GG |
GT |
TT |
GT + TT vs. GG |
T vs. G |
|||
|
Normal (N = 1150) |
0.415 |
0.341 |
0.488 |
0.171 |
7 × 10-5 |
2 × 10-4 |
1.64 (1.27-2.14) |
7.8 × 10-5 |
1.39 (1.18-1.63) |
|
AS Syn+ (N = 393) |
0.496 |
0.239 |
0.529 |
0.232 |
|||||
|
AS Syn- (N = 403) |
0.465 |
0.275 |
0.519 |
0.206 |
0.215 |
0.243 |
1.21 (0.88-1.66) |
0.217 |
1.13 (0.93-1.38) |
|
Adjusted for HLA-B27+* |
0.338 |
0.449 |
1.13 (0.82-1.57) |
0.351 |
1.10 (0.90-1.34) |
||||
|
rs27980 |
C |
AA |
AC CC |
AC + CC vs. AA |
C vs. A |
||||
|
Normal (N = 1150) |
0.538 |
0.215 |
0.493 |
0.291 |
9.9 × 10-3 |
0.011 |
1.49 (1.10-2.02) |
9.4 × 10-3 |
1.24 (1.05-1.46) |
|
AS Syn+ (N = 393) |
0.592 |
0.155 |
0.506 |
0.338 |
|||||
|
AS Syn- (N = 404) |
0.555 |
0.191 |
0.510 |
0.300 |
0.134 |
0.188 |
1.28 (0.89-1.85) |
0.134 |
1.16 (0.95-1.42) |
|
Adjusted for HLA-B27+ |
0191 |
0.311 |
1.21 (0.83-1.77) |
0.195 |
1.14 (0.93-1.40) |
||||
|
rs27044 |
G |
CC |
CG |
GG |
CG + GG vs. CC |
G vs. C |
|||
|
Normal (N = 1149) |
0.509 |
0.235 |
0.513 |
0.252 |
7 × 10-5 |
10-4 |
1.85 (1.35-2.53) |
9.8 × 10-5 |
1.38 (1.18-1.63) |
|
AS Syn+ (N = 393) |
0.589 |
0.143 |
0.537 |
0.321 |
|||||
|
AS Syn-(N = 403) |
0.552 |
0.208 |
0.479 |
0.313 |
0.136 |
0.015 |
1.59 (1.33-2.30) |
0.136 |
1.16 (0.95-1.42) |
|
Adjusted for HLA-B27+ |
0.271 |
0.050 |
1.46 (1.00-2.13) |
0.277 |
1.12 (0.91-1.37) |
||||
|
rs30187 |
T |
CC |
CT |
TT |
CT + TT vs. CC |
T vs. C |
|||
|
Normal (N = 1150) |
0.529 |
0.220 |
0.503 |
0.277 |
1.3 × 10-3 |
3 × 10-4 |
1.81 (1.31-2.50) |
1.5 × 10-3 |
1.31 (1.11-1.54) |
|
AS Syn+ (N = 393) |
0.594 |
0.135 |
0.542 |
0.323 |
|||||
|
AS Syn-(N = 404) |
0.566 |
0.203 |
0.463 |
0.334 |
0.258 |
0.011 |
1.63 (1.12-2.38) |
0.248 |
1.12 (0.92-1.37) |
|
Adjusted for HLA-B27+ |
0.463 |
0.040 |
1.50 (1.02-2.20) |
0.456 |
1.08 (0.88-1.32) |
||||
|
|
|||||||||
|
RA: Risk allele. RAF: Risk allele frequency. The case-control association tests were performed in two subsets of the samples: (1) AS patients with syndesmophyte (AS Syn+) vs. normal controls; (2) AS patients with syndesmophyte (AS Syn+) vs. AS patients without syndesmophyte (AS Syn-). *Cochran -Mantel -Haenszel (CMH) tests for ERAP1 SNP and syndesmophyte associations, controlling for HLA-B27 positivity. ** The Trend test p-values were generated from 100,000 permutations. |
|||||||||
|
Wang et al. Arthritis Research & Therapy 2012 14:R125 doi:10.1186/ar3855 |
|||||||||
