Table 3

ERAP1 SNP analyses in normal controls and AS patients positive and negative for syndesmophyte

SNP

/Group

RA

/RAF

Genotype

/Frequency

Trend test

P**

Genotype analysis

Allelic analysis

P

OR (95% CI)

P

OR (95% CI)


rs27037

T

GG

GT

TT

GT + TT vs. GG

T vs. G

Normal (N = 1150)

0.415

0.341

0.488

0.171

7 × 10-5

2 × 10-4

1.64 (1.27-2.14)

7.8 × 10-5

1.39 (1.18-1.63)

AS Syn+ (N = 393)

0.496

0.239

0.529

0.232

AS Syn- (N = 403)

0.465

0.275

0.519

0.206

0.215

0.243

1.21 (0.88-1.66)

0.217

1.13 (0.93-1.38)

Adjusted for HLA-B27+*

0.338

0.449

1.13 (0.82-1.57)

0.351

1.10 (0.90-1.34)

rs27980

C

AA

AC CC

AC + CC vs. AA

C vs. A

Normal (N = 1150)

0.538

0.215

0.493

0.291

9.9 × 10-3

0.011

1.49 (1.10-2.02)

9.4 × 10-3

1.24 (1.05-1.46)

AS Syn+ (N = 393)

0.592

0.155

0.506

0.338

AS Syn- (N = 404)

0.555

0.191

0.510

0.300

0.134

0.188

1.28 (0.89-1.85)

0.134

1.16 (0.95-1.42)

Adjusted for HLA-B27+

0191

0.311

1.21 (0.83-1.77)

0.195

1.14 (0.93-1.40)

rs27044

G

CC

CG

GG

CG + GG vs. CC

G vs. C

Normal (N = 1149)

0.509

0.235

0.513

0.252

7 × 10-5

10-4

1.85 (1.35-2.53)

9.8 × 10-5

1.38 (1.18-1.63)

AS Syn+ (N = 393)

0.589

0.143

0.537

0.321

AS Syn-(N = 403)

0.552

0.208

0.479

0.313

0.136

0.015

1.59 (1.33-2.30)

0.136

1.16 (0.95-1.42)

Adjusted for HLA-B27+

0.271

0.050

1.46 (1.00-2.13)

0.277

1.12 (0.91-1.37)

rs30187

T

CC

CT

TT

CT + TT vs. CC

T vs. C

Normal (N = 1150)

0.529

0.220

0.503

0.277

1.3 × 10-3

3 × 10-4

1.81 (1.31-2.50)

1.5 × 10-3

1.31 (1.11-1.54)

AS Syn+ (N = 393)

0.594

0.135

0.542

0.323

AS Syn-(N = 404)

0.566

0.203

0.463

0.334

0.258

0.011

1.63 (1.12-2.38)

0.248

1.12 (0.92-1.37)

Adjusted for HLA-B27+

0.463

0.040

1.50 (1.02-2.20)

0.456

1.08 (0.88-1.32)


RA: Risk allele. RAF: Risk allele frequency. The case-control association tests were performed in two subsets of the samples: (1) AS patients with syndesmophyte (AS Syn+) vs. normal controls; (2) AS patients with syndesmophyte (AS Syn+) vs. AS patients without syndesmophyte (AS Syn-). *Cochran -Mantel -Haenszel (CMH) tests for ERAP1 SNP and syndesmophyte associations, controlling for HLA-B27 positivity. ** The Trend test p-values were generated from 100,000 permutations.

Wang et al. Arthritis Research & Therapy 2012 14:R125   doi:10.1186/ar3855

Open Data