Table 2 |
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|
ERAP1 SNP analyses in Taiwanese AS patients and normal controls |
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|
SNP /Group |
RA /RAF |
Genotype /Frequency |
Trend test P* |
Genotype analysis |
Allelic analysis |
||||
|
P |
OR (95% CI) |
P |
OR (95% CI) |
||||||
|
|
|||||||||
|
rs27037 |
T |
GG |
GT |
TT |
GT + TT vs. GG |
T vs. G |
|||
|
Normal (N = 1150) |
0.415 |
0.341 |
0.488 |
0.171 |
4 × 10-5 |
9.3 × 10-5 |
1.49 (1.22-1.82) |
5.5 × 10-5 |
1.30 (1.15-1.48) |
|
AS (N = 796) |
0.481 |
0.258 |
0.524 |
0.219 |
|||||
|
rs27980 |
C |
AA |
AC |
CC |
AC + CC vs. AA |
C vs. A |
|||
|
Normal (N = 1150) |
0.538 |
0.215 |
0.494 |
0.291 |
0.035 |
0.024 |
1.31 (1.04-1.65) |
0.033 |
1.15 (1.01-1.31) |
|
AS (N = 797) |
0.573 |
0.173 |
0.508 |
0.319 |
|||||
|
rs27044 |
G |
CC |
CG |
GG |
CG + GG vs. CC |
G vs. C |
|||
|
Normal (N = 1149) |
0.509 |
0.235 |
0.513 |
0.252 |
1.7 × 10-4 |
1.7 × 10-3 |
1.44 (1.15-1.81) |
1.5 × 10-4 |
1.28 (1.13-1.46) |
|
AS (N = 796) |
0.570 |
0.176 |
0.508 |
0.317 |
|||||
|
rs30187 |
T |
CC |
CT |
TT |
CT + TT vs. CC |
T vs. C |
|||
|
Normal (N = 1150) |
0.529 |
0.220 |
0.503 0.277 |
1.6 × 10-3 |
6.1 × 10-3 |
1.38 (1.10-1.74) |
1.7 × 10-3 |
1.23 (1.08-1.40) |
|
|
AS (N = 797) |
0.580 |
0.169 |
0.502 |
0.329 |
|||||
|
|
|||||||||
|
RA: Risk allele. RAF: Risk allele frequency. * The Trend test p-values were generated from 100,000 permutations. |
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|
Wang et al. Arthritis Research & Therapy 2012 14:R125 doi:10.1186/ar3855 |
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