Table 2

ERAP1 SNP analyses in Taiwanese AS patients and normal controls

SNP

/Group

RA

/RAF

Genotype

/Frequency

Trend test

P*

Genotype analysis

Allelic analysis

P

OR (95% CI)

P

OR (95% CI)


rs27037

T

GG

GT

TT

GT + TT vs. GG

T vs. G

Normal (N = 1150)

0.415

0.341

0.488

0.171

4 × 10-5

9.3 × 10-5

1.49 (1.22-1.82)

5.5 × 10-5

1.30 (1.15-1.48)

AS (N = 796)

0.481

0.258

0.524

0.219

rs27980

C

AA

AC

CC

AC + CC vs. AA

C vs. A

Normal (N = 1150)

0.538

0.215

0.494

0.291

0.035

0.024

1.31 (1.04-1.65)

0.033

1.15 (1.01-1.31)

AS (N = 797)

0.573

0.173

0.508

0.319

rs27044

G

CC

CG

GG

CG + GG vs. CC

G vs. C

Normal (N = 1149)

0.509

0.235

0.513

0.252

1.7 × 10-4

1.7 × 10-3

1.44 (1.15-1.81)

1.5 × 10-4

1.28 (1.13-1.46)

AS (N = 796)

0.570

0.176

0.508

0.317

rs30187

T

CC

CT

TT

CT + TT vs. CC

T vs. C

Normal (N = 1150)

0.529

0.220

0.503 0.277

1.6 × 10-3

6.1 × 10-3

1.38 (1.10-1.74)

1.7 × 10-3

1.23 (1.08-1.40)

AS (N = 797)

0.580

0.169

0.502

0.329


RA: Risk allele. RAF: Risk allele frequency. * The Trend test p-values were generated from 100,000 permutations.

Wang et al. Arthritis Research & Therapy 2012 14:R125   doi:10.1186/ar3855

Open Data