Defective transforming growth factor beta-induced CD4+CD25highFoxP3+ T cells were rescued by CD200Fc. Defective transforming growth factor beta (TGF-β)-induced CD4+CD25highFoxP3+ T cells were rescued from peripheral CD4+CD25- T cells in systemic lupus erythematosus (SLE) patients by CD200Fc. Peripheral CD4+CD25- T cells were sorted from peripheral blood mononuclear cells of SLE patients or healthy controls (HCs), cultured in complete RPMI 1640 medium combined with anti-CD3/CD28, IL-2 and TGF-β in the absence or presence of CD200Fc for 7 days. Data are representative of five experiments.
Li et al. Arthritis Research & Therapy 2012 14:R123 doi:10.1186/ar3853