Effects of methotrexate on the expression of prostaglandin E2 biosynthetic enzymes in rheumatoid synovium. Immunohistochemical evaluation of positive staining for microsomal prostaglandin E2 synthase 1 (mPGES-1), cyclooxygenase 1 (COX-1), and COX-2 in synovial tissue biopsies before and 8 weeks after initiation of methotrexate treatment. Results are expressed as a percentage of the positive stained area versus the total tissue area.
Gheorghe et al. Arthritis Research & Therapy 2012 14:R121 doi:10.1186/ar3851