Research article
Elevated levels of fibrinogen-derived endogenous citrullinated peptides in synovial fluid of rheumatoid arthritis patients
1 Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University and Netherlands Proteomics Centre, Padualaan 8, Utrecht, 3584 CH, The Netherlands
2 Department of Biomolecular Chemistry, Nijmegen Center for Molecular Life Sciences, Institute for Molecules and Materials, Radboud University Nijmegen, Geert Grooteplein 26, Nijmegen, 6525 GA, The Netherlands
3 University Medical Centre Ljubljana, Department of Rheumatology, Immunology Laboratory, Vodnikova 62, Ljubljana, 1000, Slovenia
Arthritis Research & Therapy 2012, 14:R114 doi:10.1186/ar3840
Published: 14 May 2012Additional files
Additional file 1:
A PDF file containing all supplementary methods, tables and figures as referred to in the main text. The additional file contains supplementary methods on 'LC-MS/MS' and 'Identification and quantitation of endogenous peptides', a link to all identification results as deposited in the ProteomeCommons.org Tranche, supplementary tables S1 ('List of patients included and CCP status of RA patients') and S2 ('LC-MS characteristics of identified citrullinated peptides and their noncitrullinated counterparts') and supplementary figures S1 ('Abundance of fibrinogen amino acids 414-433-derived peptides in RA patients and controls'), S2 ('Relative abundance of citrullinated peptides and their noncitrullinated counterparts') and S3 ('The presence of phosphorylated and citrullinated peptides in synovial fluid').
Format: PDF Size: 491KB Download file
This file can be viewed with: Adobe Acrobat Reader
