Immunostaining of cartilage from osteoarthritic patients. Sections of human femoral condylar cartilage from six OA patients (ages 55 to 70 years), showing detection of neoepitopes generated by collagenases (C1,2C and C2C) and cathepsin K (C2K) in type II collagen. Bar = 200 μm.
Dejica et al. Arthritis Research & Therapy 2012 14:R113 doi:10.1186/ar3839