Immunostaining of cartilage from young normal individuals. Sections of human femoral condylar cartilage from six non-OA individuals (ages 19 to 47 years), showing detection of neoepitopes generated by collagenases (C1,2C and C2C) and cathepsin K (C2K) in type II collagen. Specimens are positioned so that the articular surface is at the top of each figure. Bar = 200 μm.
Dejica et al. Arthritis Research & Therapy 2012 14:R113 doi:10.1186/ar3839