Table 1 |
||
|
Distribution of FRβ in normal rat tissues analyzed using flow cytometry or immunohistochemistry |
||
|
Flow Cytometric Analysis |
FRβ |
CD11 b/c |
|
|
||
|
TGC-elicited Peritoneal mϕ |
87 ± 3.1% |
95 ± 2.5% |
|
Immunohistochemical Analysis |
FRβ |
CD68 |
|
Spleen |
||
|
White pulp |
- |
++ |
|
Red pulp mϕ |
+ |
+++ |
|
Lymph node |
||
|
Cortex, tingible body mϕ |
- |
++ |
|
Paracortical mϕ |
- |
+ |
|
Medullary mϕ |
- |
+ |
|
Subcapsular sinus mϕ |
- |
+ |
|
Brain mϕ |
- |
+ |
|
Liver mϕ (Kupffer cells) |
+ |
++ |
|
Lung |
||
|
Perivascular/peribronchial mϕ |
- |
+ |
|
Alveolar mϕ |
- |
+ |
|
Kidney |
||
|
Mesangial mϕ |
- |
+ |
|
Heart |
||
|
Myocardial mϕ |
- |
+ |
|
Endocardial mϕ |
- |
+ |
|
Colon |
||
|
Mucosa |
||
|
Epithelial mϕ |
- |
+ |
|
Lamina propria mϕ |
+ |
+ |
|
Muscularis mucosa mϕ |
- |
+ |
|
Submucosal mϕ |
- |
+ |
|
Muscularis externa mϕ |
- |
+ |
|
|
||
|
Frequency of cell staining (-, <100/10 fields), (+, 100-200/10 fields), and (++, 200-300/10 fields), (+++, >300/10 fields). Data was obtained from three normal rat tissues with similar results. FRβ, folate receptor β; TGC, thioglycollate. |
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|
Nagai et al. Arthritis Research & Therapy 2012 14:R106 doi:10.1186/ar3831 |
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