Open Access Research article

Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?

Katja Lakota1*, Jun Wei2, Mary Carns2, Monique Hinchcliff2, Jungwha Lee3, Michael L Whitfield4, Snezna Sodin-Semrl1 and John Varga2

Author Affiliations

1 Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova 62, Ljubljana 1000, Slovenia

2 Department of Medicine, Feinberg School of Medicine, Northwestern University, East Huron Street 240, Chicago, 60611-2909 IL, USA

3 Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, North Lake Shore Drive 680, Chicago, 60611-2909 IL, USA

4 Department of Genetics, Dartmouth Medical School, Remsen 7400, Hanover, 03755 NH, USA

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Arthritis Research & Therapy 2012, 14:R102  doi:10.1186/ar3827

Published: 1 May 2012

Additional files

Additional file 1:

Patient adiponectin levels according to clinical and laboratory features. Adiponectin levels evaluated statistically in different clinical and laboratory features. Significance was tested by Mann Whitney (MW) test or Kruskal Wallis (KW) test. NS = not significant. Pulmonary hypertension defined as estimated pulmonary artery systolic pressure > 40 mmHg (Echo/Doppler), or mean pulmonary artery pressure by right heart catheterization > 25 mmHg.

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Additional file 2:

Median levels of clinical/laboratory scores in patients within different adiponectin quartiles and their correlation coefficients. Correlation coefficients were determined using Spearman rank correlation test. PA = mean pulmonary artery pressure based on right heart catheterization. BNP = brain natriuretic peptide Interquartile ranges are in parentheses. NS = not significant.

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Additional file 3:

Levels of adiponectin and MRSS in the longitudinal study. Levels of adiponectin at 2 time points (visit 1: MRSS1, adiponectin 1; visit 2: MRSS 2, adiponectin 2) with an indication of time laps in between the two visits. MRSS = modified Rodnan skin score.

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