Figure 5.

Histograms showing an increase in the density of sensory and sympathetic nerve fibers in the geriatric arthritic knee joint. The length of calcitonin gene-related peptide (CGRP⁺, A) sensory nerve fibers, neurofilament 200 kDa (NF200⁺, B) sensory nerve fibers, tyrosine hydroxylase (TH⁺, C) postganglionic sympathetic nerve fibers and growth-associated protein-43⁺ (GAP-43⁺, D) nerve fibers undergoing sprouting in the synovium were obtained by manually tracing the nerve fibers in a determined volume of synovium. Bars represent the mean of at least three mice ± SEM. *P < 0.05 versus mice that received intraarticular injections of saline.