Figure 2.

Radiological destruction in 256 patients with rheumatoid arthritis (RA) at the time of diagnosis, and after one and two years. Patients are divided into those with high levels of anti-native human collagen type II (anti-CII) antibodies (n = 8, arrow in Figure 1B) and those with lower levels (n = 248). Horizontal bars indicate median levels. One patient in the anti-CII group was not investigated at two years.