Response to 'Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways'
Department of Internal Medicine, Division of Rheumatology, Eskişehir Osmangazi University, Vişnelik Mah, Alifuat Güven Cad, Akasya Sok. 11/11 Eskişehir, Turkey
Arthritis Research & Therapy 2012, 14:402 doi:10.1186/ar3862
See related research by Koskinen et al., http://arthritis-research.com/content/13/6/R184Published: 21 June 2012
First paragraph (this article has no abstract)
Different mechanisms and mediators in different stages of osteoarthritis (OA) may be involved in progression of the disease. Cross-sectional studies performed regarding cartilage degradation in OA may therefore not be generalised to whole stages. Koskinen and colleagues' study should be evaluated in light of this knowledge .